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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Phenotypically concordant distribution of pick bodies in aphasic versus behavioral dementias

Fig. 4

Abundant hippocampal pathologic burden is a universal substrate of Pick’s Disease (PiD). A Height of bars represent mean density per cubic millimeter of Pick bodies in anatomic regions in bvFTD (N = 9) and PPA cases (N = 9). Error bars represent standard errors of mean (SEM). Dotted line indicates the highest mean neocortical Pick body density from Fig. 2 for the PPA group, which was right ATL at 34,473 inclusions per mm3. Dashed line indicates the highest mean neocortical Pick body density from Fig. 2 for the bvFTD group, which was right MFG at 29,157 inclusions per mm3. bvFTD cases had slightly greater mean DG and CA1 densities compared to PPA cases, which did not reach significance. Burden was symmetric for both phenotypes. Photomicrographs (B & C) illustrate the substantial neuropathologic burden throughout the entire hippocampus in both the behavioral and aphasic phenotypes; B was obtained from Case 5, an 82-year-old female with a 12-year history of bvFTD and C was obtained from Case 12, a 65-year-old male with a 12-year history of PPA-G. Inset highlights the granule cells of the dentate gyrus, which were most affected by Pick bodies in both bvFTD and PPA cohorts. Images were taken at 1 × magnification, and insets were taken at 20X. DG = Dentate gyrus; CA1 = Cornu Ammonis field 1

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