Fig. 3

Laterality of Pick bodies in Right/Left Neocortex. A Ratios of Pick body density counts per millimeter cubed in individual right/left neocortical regions were transformed logarithmically (base 10) to illustrate hemispheric differences in PiD pathology in bvFTD (N = 9) and PPA (N = 9). In STG, right-to-left ratio was significantly different between PPA, which showed significant leftward asymmetry, and bvFTD, which showed slight rightward asymmetry (p < 0.001). The IPL ratio for Case 14 was excluded because the right IPL showed no pathology, so the right/left ratio equaled zero and thus could not be logarithmically transformed. The MFG ratio for Case 15 was excluded as an outlier (M ±  ≥ 2 SD). MFG = Middle frontal gyrus; STG = Superior temporal gyrus; IPL = inferior parietal lobule; R = Right; L = Left. ***p < 0.001. B Opposite laterality of Pick bodies in STG of PPA vs bvFTD. Photomicrographs (i) & (ii) were obtained from Case 5, an 82-year-old female with a 12-year history of bvFTD and (iii) and (iv) were obtained from Case 12, a 65-year-old male with a 12-year history of PPA-G; images highlight significant leftward asymmetry in PiD in STG, while bvFTD cases showed slight rightward predominance. Brown appearance in i and ii are due to DAB, and red appearance in (iii) and (iv) are due to Vector NovaRed substrate. Scale bar = 100 µm in (iv), and also applies to (i–iii)