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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Hippocampal capillary pericytes in post-stroke and vascular dementias and Alzheimer’s disease and experimental chronic cerebral hypoperfusion

Fig. 1

Hippocampal Pathology and Atrophy in Post-Stroke Dementia compared to other Dementias. A-B, Thal and Braak stage pathologies in different dementias compared to ageing controls and non-demented post-stroke survivors. There was significantly greater neurodegenerative pathology in Mixed (AD plus VaD) and AD cases (P < 0.01). C-D, Box plots showing hippocampal CA1 and CA3 areas relative to whole hippocampus in common dementias compared to ageing controls and non-demented post-stroke survivors. ANOVA and post-hoc tests showed that CA1 region atrophy across all dementias in PSD, VaD, Mixed and AD (P < 0.001). There was also a difference between PSD vs. PSND cases (P = 0.008). There were no significant differences in the CA3 region (D) or in CA4 or DG (not shown). Abbreviations: AD, Alzheimer’s disease, CA, cornus ammonis; DG, dentate gyrus, Mixed, mixed dementia VaD and AD; NPD, neuropathological diagnosis; PSD, post-stroke dementia; PSND, post-stroke no dementia; VaD, vascular dementia

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Acta Neuropathologica Communications

ISSN: 2051-5960

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