Fig. 8

RACK1 knockdown inhibits intercellular transmission of TDP-43^ΔNLS in HEK293T cells. a Schematic illustration of the intercellular transmission procedure. Representative western blot (WB) b and densitometric quantification show reduced total HA-tagged TDP-43^ΔNLS transmitted to naïve recipient cells c as well as a reduction in the recipient/donor ratio of TDP-43^ΔNLS upon RACK1 KD. Statistics: Student’s t-test, unpaired two-tailed. **p < 0.005; ****p < 0.0001. n = 5