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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Targeting RACK1 to alleviate TDP-43 and FUS proteinopathy-mediated suppression of protein translation and neurodegeneration

Fig. 3

Immunocytochemical analysis demonstrates reactivity of RACK1 misfolding specific antibody “RACK1mis” with RACK1 in cytoplasmic aggregates of HA-tagged TDP-43ΔNLS (middle row) or R495x-FUS (bottom row) transfected HEK293T cells but not with diffuse, non-aggregated RACK1 in the cytoplasm (stained by a Pan RACK1 antibody). RACK1mis shows no reactivity with endogenous, physiological RACK1 in un-transfected (UT, top row) cells. Nuclei stained with DAPI in merged images. Scale bars: 10 μm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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