Fig. 1
From: Nuclear face of Tau: an inside player in neurodegeneration
Role of nuclear Tau in Alzheimer’s disease. Nuclear Tau is involved in genome stability and maintenance of nucleo-cytoplasmic transport. Depletion of nuclear Tau leads to conformational changes in the heterochromatin and makes DNA vulnerable to damage, disturbs rRNA synthesis and ribonucleotide pool balance. The cytosolic Tau aggregates sequester nuclear factors leading to their depletion from the nucleus. Tau-mediated Impairment of nuclear pore complex disrupts nucleo-cytoplasmic transport, ultimately contributing to Tau-induced neurotoxicity (Created with https://www.BioRender.com)