Table 1 Statistical table

a

Figure 4i

Normal distribution

(Shapiro–Wilk p = 0.115)

t-test

p = 0.641

b

Figure 4n

Normal distribution

(Shapiro–Wilk p = 0.942)

One-way ANOVA

F(4,18) = 0.41; p = 0.801

c

Figure 5b

Normal distribution

(Shapiro–Wilk p = 0.222)

t-test

p = 0.038

d

Figure 5c

Non-normal distribution

(Shapiro–Wilk p < 0.0001)

Mann–Whitney U

Adjusted p values:

Section 1: p = 0.900

Section 2: p = 0.900

Section 3: p = 0.664

Section 4: p = 0.195

Section 5: p = 0.121

Section 6: p = 0.201

Section 7: p = 0.900

e

Figure 5e

Non-Normal distribution

(Shapiro–Wilk p = 0.016)

Mann–Whitney U

Adjusted p values:

p ≥ 0.771

f

Figure 5f

Non-normal distribution

(Shapiro–Wilk p < 0.0001)

Mann–Whitney U

Adjusted p values:

d2: p = 0.750

d7: p = 0.051

d14: p = 0.0004

g

Figure 5g

Non-normal distribution

(Shapiro–Wilk p < 0.0001)

Mann–Whitney U

Adjusted p values:

d2: p = 0.715

d7: p = 0.058

d14: p = 0.0003

h

Figure 5h

Normal distribution

(Shapiro–Wilk p = 0.109)

Two-way RM ANOVA

Time x Treatment interaction: F(2,54) = 0.13; p = 0.878

i

Figure 5i

Normal distribution

(Shapiro–Wilk p = 0.172)

Two-way RM ANOVA

Time x Treatment interaction: F(2,54) = 0.01; p = 0.993

j

Figure 5j

Normal distribution

(Shapiro–Wilk p = 0.241)

Two-way RM ANOVA

Time x Treatment interaction: F(3,81) = 0.39; p = 0.760

k

Figure 6b

Normal distribution

(Shapiro–Wilk p = 0.674)

t-test

p = 0.006

l

Figure 6c

Non-normal distribution

(Shapiro–Wilk p < 0.0001)

Mann–Whitney

Adjusted p values:

Section 1: p = 0.244

Section 2: p = 0.244

Section 3: p = 0.209

Section 4: p = 0.209

Section 5: p = 0.113

Section 6: p = 0.209

Section 7: p = 0.244

m

Figure 7b

Normal distribution

(Shapiro–Wilk p = 0.833)

t-test

p < 0.0001

n

Figure 7c

Normal distribution

(Shapiro–Wilk p = 0.908)

t-test

p < 0.0001

o

Figure 7d

Normal distribution

(Shapiro–Wilk p = 0.900)

t-test

p < 0.0001

p

Figure 7e

Normal distribution

(Shapiro–Wilk p = 0.167)

t-test

p < 0.0001

q

Figure 7f

Non-Normal distribution

(Shapiro–Wilk p = 0.025)

Mann–Whitney U

p = 0.005

r

Figure 7g

Non-Normal distribution

(Shapiro–Wilk p = 0.032)

Mann–Whitney U

p = 0.511

s

S Fig. 2c

Normal distribution

(Shapiro–Wilk p = 0.480)

t-test

p = 0.038

t

S Fig. 3b

Non-Normal distribution

(Shapiro–Wilk p = 0.007)

Mann–Whitney U

p = 0.015

u

S Fig. 3c

Non-Normal distribution

(Shapiro–Wilk p < 0.0001)

Mann–Whitney U

Adjusted p values:

30 min: p = 0.004

1 h: p = 0.004

v

S Fig. 4b

Non-Normal distribution

(Shapiro–Wilk p = 0.004)

Mann–Whitney U

Adjusted p values:

p ≥ 0.111

w

S Fig. 4c

Normal distribution

(Shapiro–Wilk p = 0.099)

Two-way RM ANOVA

(Mixed-effects model)

Time x Treatment interaction:

F(3,38) = 2.66; p = 0.062

x

S Fig. 4d

Non-Normal distribution

(Shapiro–Wilk p = 0.044)

Mann–Whitney U

Adjusted p values:

p ≥ 0.151

y

S Fig. 4e

Non-Normal distribution

(Shapiro–Wilk p = 0.018)

Mann–Whitney U

Adjusted p values:

p ≥ 0.733

z

S Fig. 4f

Non-Normal distribution

(Shapiro–Wilk p = 0.012)

Mann–Whitney U

Adjusted p values:

p ≥ 0.340

aa

S Fig. 4g

Non-Normal distribution

(Shapiro–Wilk p = 0.0005)

Mann–Whitney U

Adjusted p values:

p ≥ 0.419

ab

S Fig. 4h

Normal distribution

(Shapiro–Wilk p = 0.159)

Two-way RM ANOVA

(Mixed-effects model)

Time x Treatment interaction: F(3,38) = 0.70; p = 0.555

ac

S Fig. 4i

Non-Normal distribution

(Shapiro–Wilk p = 0.0006)

Mann–Whitney U

Adjusted p values:

p ≥ 0.186

ad

S Fig. 4k

Non-Normal distribution

(Shapiro–Wilk p < 0.0001)

Mann–Whitney U

Adjusted p values:

p ≥ 0.999

ae

S Fig. 4l

Non-Normal distribution

(Shapiro–Wilk p < 0.0001)

Mann–Whitney U

Adjusted p values:

p ≥ 0.997

af

S Fig. 5b

Normal distribution

(Shapiro–Wilk p = 0.715)

t-test

p = 0.093