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Table 1 The study population consisted of individuals from two previous publications and newly included individuals, as summarised here

From: Cortical microvascular raspberries and ageing: an independent but not exclusive relationship

Publication

n

Age range

Inclusion period

Study population

Ek Olofsson et al. [2]

62

46–97

April 2019–January 2021

Patients who had undergone a neuropathological examination where tissue sections from ≥ 10 different brain regions had been sampled—including a tissue section from the anterior frontal lobe—and the brain weight had been documented. Furthermore, a complete diagnostic autopsy report and access to clinical data from the medical records was required. No specific diagnosis was sought

Ek Olofsson et al. [3]

131*

57–92

January 1993–September 2021

Patients that could be fit into one of three groups based on their status regarding cerebral atherosclerosis and acute circulatory failure and matched with patients from the other two groups according to age, sex, and examined brain region

Newly included

70

20–59

January 2013–April 2023

Patients who were 20–59 years old at the time of death and had undergone a neuropathological examination in which one of the sampled tissue sections were from the frontal lobe

Total

263

20–97

January 1993–April 2023

Adult patients who had undergone a clinical autopsy including a diagnostic neuropathological examination at the Section of Clinical Pathology, Region Skane, Lund

  1. *The original study sample consisted of 141 cases. Of these, fifteen had had their cortical raspberry density quantified in another region than the frontal lobe. In five of these cases, a tissue section from the frontal lobe was available, and the raspberry density could be measured retrospectively in this region. The remaining ten cases were excluded