Fig. 6

Comparison of cortex- and striatum-derived astrocytes from MBP29-hα-syn mice. A Functional gene set enrichment analysis based on DEGs. Striatal transcripts were compared to cortical transcripts and subsequently enriched in hallmark pathways and biological processes. Most significant enrichment of striatal transcripts were observed in pathways associated with a pro-inflammatory response and energy homeostasis, implying a more pronounced reactivity in striatum compared to the cortex. B Venn-diagram of overlapping genes of striatal and cortical transcripts derived from displaying 79 shared differentially expressed genes. Overrepresentation analysis of the non-overlapping genes (973 striatal, 573 cortical genes) displaying the top 8 overrepresented pathways sorted by the count of enriched transcript. Color code is based on the adj. p-value