Cerebrospinal fluid shotgun proteomics identifies distinct proteomic patterns in cerebral amyloid angiopathy rodent models and human patients

Table 3 Overview of all fifteen overlapping differentially expressed proteins between rTg-DI rats and human sCAA patients, as compared to their respective controls

Protein ID	Protein name	rTg-DI 3 M		rTg-DI 6 M		rTg-DI 12 M		sCAA
Protein ID	Protein name	p-Value	Ratio	p-Value	Ratio	p-Value	Ratio	p-Value	Ratio
APLP2^#	Amyloid beta precursor like protein 2	–	–	–	–	*	0.5	*	0.8
BCAN^#	Brevican	***	0.6	–	–	–	–	**	0.7
CD44^#	Cluster of differentiation 44	–	–	–	–	**	1.5	*	1.1
CPE	Carboxypeptidase E	*	0.5	–	–	–	–	**	0.8
MDH1^#	Malate dehydrogenase 1	–	–	–	–	*	0.3	*	0.8
PCOLCE^#	Procollagen C–Endopeptidase enhancer	*	0.7	–	–	–	–	*	0.9
SCG5^#	Secretogranin-5	–	–	–	–	*	0.8	**	0.8
SELENBP1^#	Selenium binding protein 1	–	–	–	–	*	0.6	**	0.6
SERPING1^#	Serpin Family G Member 1	*	0.6	–	–	–	–	*	0.9
APP	Amyloid precursor protein	***	2.7	***	3.6	*	2.0	***	0.7
CLU	Clusterin	–	–	–	–	*	2.0	**	0.8
CSPG5	Chondroitin Sulfate Proteoglycan 5	–	–	*	1.4	–	–	*	0.8
FAM3C	Family with sequence similarity 3 member C	–	–	*	1.3	–	–	*	0.9
IGFALS	Insulin–like growth factor binding protein acid labile subunit	–	–	*	0.7	*	0.5	*	1.2
LCAT	Lecithin–Cholesterol Acyltransferase	–	–	–	–	**	1.8	*	0.7

Wilcoxon-signed rank tests were performed for comparison of non-parametric data. ***p ≤ 0.001, **p ≤ 0.01, ***p ≤ 0.05, ns non-significant, FC Fold-change rTg-DI/WT. ^#Proteins with an identical direction of fold-change between rTg-DI/WT and sCAA/CON. Ratio Ratio rTg-DI/WT or sCAA/CON

ISSN: 2051-5960