Fig. 3

Differentially expressed proteins in the CSF of rTg-DI models. (A) Venn diagram comparing differentially expressed proteins between rTg-DI and WT rats at 3 months (3M; n = 6/10), 6 months (6M; n = 8/8), and 12 months (12 M; n = 10/10) of age. (B) Venn diagram comparing differentially expressed proteins between age groups within rTg-DI (n = 6/8/10) and WT models (n = 10/8/10). Significance defined as p ≤ 0.05 by Wilcoxon signed rank test. (C-E) Scatterplots of the prominently differential cathepsin family of proteins. Cathepsins B, D and S (CTSB; CTSD; CTSS) and their inhibitor Cystatin-C (CST3) all were differential between rTg-DI rats and WT littermates at multiple ages. ***p < 0.001. **p < 0.01, *p < 0.05, ns not significant