Fig. 1

Study design of proteomic cerebrospinal fluid (CSF) analysis in rTg-DI models. Group sizes of 6/10, 8/8 and 10/10 were available for rTg-DI (rat CAA type I model) and WT (wild-type) models respectively. Additionally, 39 patients with sCAA (sporadic CAA) and 28 age- and sex-matched controls were included for analysis of human CSF. CSF was sampled, digested and analysed using shotgun proteomics on an Evosep-timsTOF setup. Proteins were identified and visualized using scatter and volcano plots, as well as principal component analysis