Fig. 5

DX2 transgenic mice show neuroprotective effect A Schedule of rotenone-based PD induction in DX2 transgenic mice. B Rotarod analysis. Latency to fall in rotenone-treated wild type and DX2 transgenic (TG) mice. C TH expression was analyzed in the substantia nigra region of indicated mice. The scale bar: 50 μm. D and E Relative TH-positive staining intensity between control and rotenone-treated wild-type animals. E Relative TH-positive staining intensity between control and rotenone-treated DX2-TG animals. F and G The Pole test. Vertical movement and T-turn time in rotenone-treated wild type and DX2 TG mice. Animals: n = 6 (in each group); ns non-significant; *P < 0.05; **P < 0.01; ***P < 0.001