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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Histone acetylation in an Alzheimer’s disease cell model promotes homeostatic amyloid-reducing pathways

Fig. 2

Differences between APPDup and NDC neurons. A APPDup day 21 neurons secrete more Aβ42 than NDC day 21 neurons (p = 0.0013, two-tailed T-test) at baseline. Media from CTRL RNAi-treated day 21 neurons was collected and measured via enzyme-linked immunosorbent assay (ELISA) and measured Aβ42 abundance was normalized to BCA. B Volcano plot depicting DEGs between APPDup and NDC day 21 neurons. Significance and fold-change threshold of p-adj. < 0.005 and log2FC > 0.75 were used. C, D Bubble plots depicting the top 25 ConsensusPathDB-identified over-represented terms in NDC-neuronoverexpressed (C) and APPDup neuron-overexpressed (D) genes. Neuron-related and tyrosine metabolismrelated terms are highlighted with an asterisk

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Acta Neuropathologica Communications

ISSN: 2051-5960

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