Fig. 3

Ultrastructure of mitochondria in the axons of peripheral nerves. Longitudinal section of the sural nerves obtained from a patient 1 and b a control, and c the patient’s posterior root. a’–c’ The magnified images. In the patient, a mitochondria are located in the periphery within the axon and a’ show aberrant aggregation and circularization (arrowhead), while b mitochondria are randomly distributed within the axon and b’ appear normally elongated in the control (arrowheads). c, c’ In the posterior root, similar abnormal mitochondria are scattered (arrowheads). Ctrl, control; Pt, patient. Bar in c = 2.5 μm for a, b, c; 500 nm for a’, b’, c’