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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Transformation of non-neuritic into neuritic plaques during AD progression drives cortical spread of tau pathology via regenerative failure

Fig. 7

Comparison of transcriptomic pathways between control, non-NP and NP. a Calcium-dependent events and b neuronal system related gene heatmap from NanoString DSP compared between control (no plaque) microenvironment, NP microenvironment, and non-NP microenvironment. Log2 change from mean shows non-NP microenvironment is most downregulated in both Calcium dependent genes and neuronal system genes, followed by NP microenvironment and then control. Sample size (n) = 6. c Spatial Decon algorithm derived from the NanoString DSP shows cell type proportion in control, NP and non-NP microenvironment

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Acta Neuropathologica Communications

ISSN: 2051-5960

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