Table 1 Demographics and omics-based/clinical phenotypes for the samples assigned to each cluster for each dataset
| Â | KCL BrainBank (motor cortex) | TargetALS (motor cortex) | Zucca (blood) | van Rheenen (blood) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | |
Number of Samples (%) | 60 (53.57) | 28 (25.00) | 24 (21.43) | 97 (57.7) | 28 (16.6) | 43 (25.6) | 13 (86.70) | 1 (6.65) | 1 (6.65) | 335 (84.4) | 33 (8.31) | 29 (7.31) |
Number of Samples with a posterior probability ≥ 80% (%) | NA | NA | NA | 88 (90.7) | 22 (78.6) | 31 (72.1) | 9 (69.2) | 1 (100) | 0 (0) | 275 (82.1) | 31 (93.9) | 11 (37.9) |
N Males: N Females (Ratio) | 35:25 (1.4) | 15:13 (1.15) | 15:9 (1.67) | 60:37 (1.62) | 18:10 (1.80) | 21:22 (0.95) | 6:7 (0.86) | 0:1 (0) | 1:0 (0) | 205:130 (1.58) | 18:15 (1.20) | 16:13 (1.23) |
C9 positive individuals (N) | 7 | 1 | 0 | 11 | 0 | 4 | NA | NA | NA | NA | NA | NA |
Age at Symptom Onset in Years (mean ± SD) | 58.8 ± 11.6 | 65.7 ± 12.3 | 61.7 ± 15.7 | 59.6 ± 11.1 | 64.9 ± 9.52 | 60.3 ± 11.5 | 63.6 ± 8.6 | 67.0 ± 0.0 | 65.0 ± 0.0 | 62.7 ± 11.9 | 57.9 ± 12.0 | 60.9 ± 12.3 |
Age at Blood Draw in Years (mean ± SD) | NA | NA | NA | NA | NA | NA | 66.1 ± 9.8 | 69.0 ± 0.0 | 68.0 ± 0.0 | NA | NA | NA |
Age At Death in Years (mean ± SD) | 62.5 ± 11.4 | 70.2 ± 11.4 | 64.2 ± 15.6 | 63.2 ± 10.2 | 69.5 ± 9.0 | 64.5 ± 8.9 | NA | NA | NA | NA | NA | NA |
Limb Onset (N) | 36 | 10 | 17 | 65 | 22 | 17 | NA | NA | NA | 215 | 21 | 15 |
Bulbar Onset (N) | 15 | 7 | 5 | 14 | 5 | 21 | NA | NA | NA | 120 | 12 | 14 |
Limb + Bulbar Onset (N) | 1 | 1 | 0 | 7 | 0 | 1 | NA | NA | NA | NA | NA | NA |
Diagnostic Delay in Years (mean ± SD) | 0.0015 ± 0.0013 | 0.00047 ± 0.00085 | 0.001 ± 0.0012 | 0.025 ± 0.32 | 0.073 ± 0.59 | 0.12 ± 0.35 | NA | NA | NA | NA | NA | NA |
Disease Duration in Years (median (IQR)) | 3.16 (1.96) | 2.30 (1.81) | 2.38 (1.75) | 3.00 (2.13) | 4.00 (3.48) | 2.00 (2.00) | NA | NA | NA | 2.41 (2.02) | 2.47 (1.14) | 2.37 (1.53) |
Post-mortem Delay in Hours (mean ± SD) | 26.1 ± 12.10 | 26.0 ± 10.70 | 25.9 ± 13.90 | 9.9 ± 6.10 | 10.0 ± 7.45 | 12.0 ± 8.26 | NA | NA | NA | NA | NA | NA |
Mitochondrial DNA Copy Number (mean ± SD) | 465 ± 22.0 | 457 ± 22.4 | 459 ± 17.3 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Telomere Length in Kilobytes (mean ± SD) | 4.04 ± 0.46 | 3.98 ± 0.56 | 3.77 ± 0.42 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Transcriptional Age Acceleration in Years (mean ± SD) | 6.16 ± 9.24 | 0.45 ± 10.90 | 5.59 ± 10.80 | 10.50 ± 8.63 | 4.19 ± 8.08 | 8.54 ± 8.44 | -23.50 ± 9.90 | -28.60 ± 0.00 | -26.93 ± 0.00 | -41.21 ± 11.66 | -36.68 ± 11.84 | -38.62 ± 11.69 |
Biological Age Acceleration in Years (mean ± SD) | 5.99 ± 2.92 | 4.06 ± 4.65 | 7.93 ± 4.67 | NA | NA | NA | NA | NA | NA | NA | NA | NA |