Fig. 6

Synthesis and anti-tumor effect of nanoparticle-miR-211 conjugates in MB cells. A Schematic of lipid-based (lipid), polymeric (dendrimer), or inorganic (cerium oxide)-miR-211 conjugate synthesis. B Expression of miR-211 in D425 cells treated with nanoparticle-miR-211 conjugates at different concentrations and time points by qRT-PCR. C The effect of 1 μM CNP-, dendrimer-, LNP-miR-211 on the viability of D425 cells by MTS assays. D Percentages of early and late apoptotic cells were determined by Annexin V/PI assays in D425 cells treated with 1 μM CNP-, dendrimer-, and LNP-miR-211 conjugates. E The effect of 1 μM CNP-, dendrimer-, LNP-miR-211 conjugates on the invasion of D425 cells in transwell assays. Data, mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, NS, non-significant