Table 1 Sociodemographic and clinical characteristics of the sample (n = 648)

Age (y), Mean ± SDª

74.7 ± 12.0

74.5 ± 12.0

75.0 ± 11.5

0.62

Education (y), Mean ± SDª

4.4 ± 3.7

4.6 ± 3.8

3.7 ± 3.4

0.01

Sex (%)^b

  Female

52.3

52.6

51.6

0.90

Race (%)^c

0.001

  White

68.5

72.1

59.3

  Black

28.7

24.7

39.0

  Asian

2.8

3.2

1.7

Hypertension (%)^b

65.1

63.9

68.1

0.36

Diabetes (%)^b

28.9

30.3

25.3

0.25

Dyslipidemia (%)^b

9.7

9.23

11.0

0.59

Heart disease (%)^b

31.3

31.8

30.2

0.78

Stroke (%)^b

14.2

14.4

13.7

0.93

BMI (kg/m²), Mean ± SDª

23.2 ± 5.0

23.3 ± 5.1

23.1 ± 5.0

0.60

Physical inactivity (%)^b

51.2

49.4

56.0

0.15

Smoking (%)^b

0.76

  Never

49.1

48.3

51.1

  Current

19.8

20.4

18.1

  Former

31.2

31.3

30.8

Alcohol use (%)^b

0.94

  Never

59.1

58.8

59.9

  Current

23.0

23.0

23.1

  Former

17.9

18.2

17.0

CDR ≥ 0.5 (%)^b

30.7

26.4

41.8

 < 0.001

Braak & Braak score (%)^b

 < 0.001

  0-II

59.3

63.1

49.5

  III-IV

27.9

27.0

30.2

  V-VI

12.8

9.9

20.3

CERAD score (%)^b

 < 0.001

  None or Sparse

71.8

78.3

54.9

  Moderate

15.6

13.9

19.8

  Frequent

12.7

7.7

25.3

TDP-43 (%)^b*

12.3

11.6

14.3

0.67

Lewy body disease (%)^b**

12.8

12.7

13.1

1.00

Lacunar Infarcts (%)^b

11.6

10.3

14.8

0.14

Hyaline arteriosclerosis (%)^b

21.1

21.9

19.2

0.52

Cerebral Amyloid Angiopathy (%)^b

7.1

4.5

13.7

 < 0.001