Fig. 2

Associations of the Apolipoprotein E gene ε4 allele (APOE-ε4) with Clinical Dementia Rating (CDR) and neurodegenerative lesions. Compared to APOE ε4 non-carriers, APOE-ε4 carriers had A more cognitive impairment (CDR = 0.5) and probable dementia (CDR ≥ 1) (p < 0.001), B higher frequency of Braak staging ≥ III (p < 0.001), C moderate and frequent neuritic plaques (p < 0.001), and D cerebral amyloid angiopathy (p < 0.001). Chi-square tests were used for all comparisons