Variant allelic frequencies of driver mutations can identify gliomas with potentially false-negative MGMT promoter methylation results

Table 2 Analysis of differentially dissected tumor samples

Sample	TERT promoter mutation	High cellularity area			Low cellularity area
Sample	TERT promoter mutation	Microscopic cellularity	TERT VAF	MGMT level, %	Microscopic cellularity	TERT VAF	MGMT level, %
1	c.-124 C > T	60%	0.311	52.213	10%	0.152	18.800
2	c.-124 C > T	80%	0.214	30.332	20%	0.077	4.553
3	c.-124 C > T	80%	0.376	59.323	5%	0.056	11.865
4	c.-124 C > T	60%	0.386	67.633	40%	0.440	75.486
5	c.-124 C > T	90%	0.315	68.293	50%	0.263	57.687

All MGMT ddPCR results were positive, in both high- and low-cellularity areas of tumors

ISSN: 2051-5960