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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Variant allelic frequencies of driver mutations can identify gliomas with potentially false-negative MGMT promoter methylation results

Fig. 6

Central hypothesis. MGMT promoter methylation is pathologic, and occurs only in tumor cells. Cellular glioma samples are rich in DNA from tumor cells, whereas paucicellular glioma samples contain a large fraction of DNA from non-tumor cells, which can “dilute” positive methylation signals from tumor cell DNA, leading to false-negative results

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Acta Neuropathologica Communications

ISSN: 2051-5960

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