Fig. 5

Functional identification of MB-R vulnerabilities by HTS. A Distribution of 303 active compounds (5th percentile of all ranked compounds), selected from primary HTS, tested in dose–response experiments, and arranged according to their target/mechanism of action. Each compound is represented as a coloured dot, with increased potency against n MB-R models represented by progressively darker red and increased activity against MB-S cells shown by green color. B Enrichment map summarizing transcriptional GSEA results (p < 0.05) performed in a subset of Gene Set terms (across the C2cp, and C5bp MsigDB gene set collections) correlated to the antimetabolites function, grouped according to their similarity