Fig. 8

Combination therapy of UNC2025 and TSA decreases expression of meningioma EMT-related markers. a Representative western blot and b quantification showing E-cadherin, Notch1 (FL and NICD), Slug, Snail and N-cadherin expression in WHO grade 1 spheroids after combination therapy UNC2025 and TSA at a concentration of 0.5 µM. c Representative western blot and d quantification showing E-cadherin, Notch1 (FL and NICD) and slug expression in WHO grade 2 spheroids after combination therapy using UNC2025 and TSA at a concentration of 1 µM. GAPDH was the loading control. Paired t-test was used for statistical evaluation: *p < 0.05, **p < 0.01, ***p < 0.001, ns = not significant, FL = full length., NICD = Notch intracellular domain