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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Deep histopathology genotype–phenotype analysis of focal cortical dysplasia type II differentiates between the GATOR1-altered autophagocytic subtype IIa and MTOR-altered migration deficient subtype IIb

Fig. 2

Autophagocytic phenotype in DEPDC5 altered FCDIIa. Images were taken from a 42-year-old male individual with drug-resistant focal epilepsy and FCDIIa, DEPDC5 altered (ID3). A juxtanuclear accumulation of autophagosomes can be anticipated from the displacement of neurofilaments (arrow in A as an example, NF-SMI32) and silver impregnation (arrow in B, Bielschowski silver staining, see also higher magnification in E). C p62-immunoreactivity highlighted the aggregation of autophagosomes in FCDIIa. D Further confirmation of the autophagocytic phenotype in FCDIIa by double immunofluorescence and laser scanning microscopy of NF-SMI32 (in red) and p62 (in green). Scale bar in A and B = 100 µm. The scale bar in C = 25 µm, applies also to (D) and (E)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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