Accurate digital quantification of tau pathology in progressive supranuclear palsy

Table 9 Spearman’s correlation coefficients between tau density and region-specific severity rating

Tau type	GP	STN	PU	DN	PF	OC
Total tau density	0.69*	0.66*	0.87**	0.51*	0.83**	0.84**
Tau hallmark density	0.62*	0.44 (p = 0.06)	0.83**	0.58*	0.73**	0.80**
CB density	0.62*	0.50*	0.79**	0.63*	0.63*	0.79**
NFT density	0.50*	0.20 (p = 0.42)	0.61*	0.56*	0.44*	0.72**
TA density	N/A	N/A	0.87**	N/A	0.81**	0.84**
TF density	0.67*	0.66*	0.87**	0.48*	0.81**	0.82**

Measures were quantified from each region in the PSP staging system. GP Globus pallidus, STN subthalamic nucleus, PU putamen, DN dentate nucleus, PF pre-frontal and OC occipital region. *Correlations are significant at p < 0.05, **Correlations are significant at p < 0.00. Not applicable (N/A) where TA density is not quantifiable. CB coiled body, NFT neurofibrillary tangle, TA tufted astrocyte, TF tau fragments

ISSN: 2051-5960