Accurate digital quantification of tau pathology in progressive supranuclear palsy

Table 8 Spearman’s correlation coefficients between tau density and the overall PSP stage

Tau type	GP	STN	PU	DN	PF	OC
Total tau density	0.19 (p = 0.41)	0.34 (p = 0.13)	0.28 (p = 0.22)	0.63**	0.70**	0.85**
Tau hallmark density	0.30 (p = 0.19)	0.51*	0.37 (p = 0.10)	0.71**	0.75**	0.81**
CB density	0.30 (p = 0.19)	0.49*	0.37 (p = 0.10)	0.72**	0.67**	0.79**
NFT density	0.12 (p = 0.61)	0.12 (p = 0.60)	0.53*	0.68**	0.54*	0.69**
TA density	N/A	N/A	0.33 (p = 0.14)	N/A	0.73**	0.83**
TF density	0.16 (p = 0.48)	0.34 (p = 0.13)	0.27 (p = 0.24)	0.60*	0.67**	0.84**

Tau density was quantified from each region in the PSP staging system. GP Globus pallidus, STN subthalamic nucleus, PU putamen, DN dentate nucleus, PF pre-frontal and OC occipital region. *Correlations are significant at p < 0.05, **Correlations are significant at p < 0.001. Not applicable (N/A) where TA density is not quantifiable. CB coiled body, NFT neurofibrillary tangle, TA tufted astrocyte, TF tau fragments

ISSN: 2051-5960