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Table 1 Clinical and neuropathological data of donor participants with pathological diagnosis of PSP in the study

From: Accurate digital quantification of tau pathology in progressive supranuclear palsy

Subject

Age at death (years)

Gender

Clinical diagnosis

Disease duration (years)

Last PSPRS Total

PSPRS to death (years)

Pathological stage

GP

STN

STR

PF

DN

OC

1

76

Female

prob. PSP-RS

8.75

63

0.32

2

2

2

2

0

1

0

2

75

Male

poss. PSP-PGF

4.62

26

0.52

2

3

3

2

0

1

0

3

55

Female

prob. PSP-RS

5.5

53

0.41

3

2

2

2

1

1

0

4

74

Male

prob. PSP-RS

6

45

0.67

3

2

2

2

1

1

0

5

72

Male

prob. PSP-RS

N/A

N/A

N/A

3

N/A

N/A

N/A

N/A

N/A

N/A

6

65

Female

prob. PSP-RS

13.92

54

0.75

4

2

3

2

1

N/A

0

7

78

Male

poss. PSP-CBS

5.75

43

0.69

4

3

3

3

3

2

0

8

79

Female

poss. PSP-CBS

3.42

49

0.74

4

2

2

2

1

2

0

9

77

Male

prob. PSP-RS

6.33

55

0.74

4

3

3

2

2

3

0

10

78

Male

prob. PSP-RS

5.33

54

0.56

4

2

2

2

1

2

0

11

80

Male

prob. PSP-RS

6.5

62

0.11

4

2

3

2

1

2

0

12

71

Female

prob. PSP-RS

4.58

45

0.13

4

2

3

3

1

2

0

13

75

Female

poss. PSP-CBS

2.83

N/A

N/A

4

3

N/A

2

1

2

0

14

64

Male

prob. PSP-RS

5.08

38

1.09

4

2

N/A

2

2

3

0

15

80

Male

prob. PSP-RS

11.92

76

1.3

4

2

3

2

1

2

0

16

71

Male

prob. PSP-RS

5.17

38

2.21

5

2

3

2

3

2

1

17

78

Female

poss. PSP-SL

8.83

72

1.94

5

3

3

3

3

3

1

18

63

Male

prob. PSP-RS

8.83

62

2.44

5

3

3

3

2

3

1

19

76

Male

prob. PSP-RS

3.87

51

0.42

5

3

3

3

3

3

1

20

74

Female

prob. PSP-RS

6.58

58

2.66

5

2

2

2

2

2

1

21

88

Male

prob. PSP-RS

5.08

53

0.3

5

2

N/A

2

2

2

1

22

69

Female

prob. PSP-RS

5.33

51

0.36

5

3

3

3

2

3

1

23

71

Female

prob. PSP-RS

6.17

60

0.05

5

2

N/A

2

2

3

1

24

71

Male

prob. PSP-RS

5.42

43

1.89

5

3

3

3

3

3

1

25

73

Male

poss. PSP-CBS

4

NA

NA

5

3

3

3

3

3

1

26

78

Female

poss. PSP-CBS

5

48

0.18

5

3

3

3

1

3

1

27

84

Male

prob. PSP-RS

8.75

59

2.42

5

3

3

3

2

3

1

28

84

Female

prob. PSP-RS

4.25

67

0.78

5

3

3

3

3

3

1

29

78

Female

prob. PSP-RS

16.75

52

0.99

5

3

3

3

3

2

1

30

78

Male

poss. PSP-CBS

N/A

N/A

N/A

5

N/A

N/A

N/A

N/A

N/A

N/A

31

80

Female

poss. PSP-CBS

8.42

73

0.23

6

3

3

2

2

3

2

32

75

Male

prob. PSP-F

8.42

81

0.76

6

3

3

3

3

3

2

  1. Not applicable (N/A) where data is not available in the database. Severity rating for each brain region includes 0 = absence, 1 = mild, 2 = moderate, 3 = severe. For clinical diagnosis of PSP participants, prob. probable, poss. possible, s.o. suggestive of, RS Richardson syndrome, CBS predominant corticobasal syndrome, SL predominant speech and language disorder, F predominant frontal presentation, PGF progressive gait freezing. PSPRS PSP rating scale (clinical severity measure). GP Globus pallidus, STN Subthalamic nucleus, STR Striatum, PF pre-frontal, DN Dentate nucleus, OC Occipital
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Acta Neuropathologica Communications

ISSN: 2051-5960

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