Fig. 8
From: EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting receptor degradation in glioblastoma
Validation of EMP3's effects on total and phosphorylated EGFR using TCGA data. A Scatter plot showing upregulated proteins (difference in RPPA scores > 0; P < 0.05) in EMP3-high vs. EMP3-low TCGA IDH-wt GBM tumors. Tumors were classified into either group using the median EMP3 expression level based on the TCGA Agilent-4502A microarray data as cutoff. B, C Representative bar plots showing the RPPA scores of Tyr1068-phosphorylated (B) and total EGFR (C) in EMP3-high vs. EMP3-low IDH-wt GBMs. Figures were obtained from the GlioVis portal version 0.20 (http://gliovis.bioinfo.cnio.es/, accessed 09 July 2022)