Fig. 4

Quantitative analyses of motor cortical pTDP-43 morphologies in ALS-TDP subgroups. A significantly greater burden of pTDP-43 granulofilamentous neuronal inclusions (GFNIs) and grains were found in ALS-TDP type E (n = 11) compared to ALS-TDP type B (n = 35) and ALS-TDP type SC (n = 8) cases, even when when the two ALS-TDP type E cases with the most severe pathology were excluded from analysis (p ≤ 0.005) ( A- B). No significant difference in pTDP-43 neuronal cytoplasmic inclusions (NCIs) were found between groups ( C). Semi-quantitative analysis of pTDP-43 burden revealed a similar burden of pathological pTDP-43 in the superficial and deep layers within subtypes ( D- F). **p ≤ 0.005