Fig. 2

Micrographs of the characteristic pathologies observed in the motor cortex of ALS-TDP subtypes. Cases with ALS-TDP type E demonstrated a predominant pattern of pTDP-positive granulofilamentous neuronal inclusions (GFNIs, asterix) and grains (white arrowhead) not identified on corresponding p62-immunostained sections in both C9ORF72-carriers and non-carriers. Cases with ALS-TDP type B had a predominant pattern of round neuronal cytoplasmic inclusions (black arrowhead) and occasional dystrophic neurites (arrow) that were observed throughout the cortical layers of both pTDP-43 and p62 immunostained sections in both C9ORF72-carriers and non-carriers. Cases with ALS-TDP type SC (scarce cortical) had scarce pTDP-43 and p62 aggregates that could not be subtyped