Fig. 1

A schematic illustration of the motor cortex for the classification of ALS-TDP subtypes. Cases with a predominant pattern of pTDP-positive granulofilamentous neuronal inclusions (GFNIs) and grains not identified on corresponding p62-immunostained sections were assigned a type E; cases with round neuronal cytoplasmic inclusions ± few dystrophic neurites that were observed throughout the cortical layers of both pTDP-43 and p62 immunostained sections were assigned a type B; cases with scarce pTDP-43 and p62 aggregates that were insufficient for subclassification were assigned a type SC (scarce cortical)