Fig. 2

Type-2b-fiber atrophy and increased numbers of tissue macrophages in skeletal muscles of patients with PCS. ATP4.6 enzymatic reaction showing selective atrophy of type-2b muscle fibers in PCS samples and the 2BA control cohort (A). Immunohistochemistry and quantification of CD68⁺ and CD169⁺ macrophages (B). Immunohistochemistry and quantification of CD206⁺, CD45⁺ and CD8⁺ cells (C). 400 × magnification, scale bar = 100 µm. Immunohistochemistry, semi-quantitative scoring of sarcolemmal MHC-cl.-I expression and example with a score of 2 (D). 100 × magnification, black scale bar = 200 µm. Ordinary one-way ANOVA with Tukey's multiple comparisons test. * = p < 0.05, ** = p < 0.005, *** = p < 0.0005. ATP4.6 Adenosine 5'-TriPhosphatase at pH 4.6, SIGLEC1 Sialoadhesin, MHC cl. I Major histocompatibility complex class I