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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice

Fig. 4

RNAseq analysis of the temporal cortex from PS19 mice treated with ASO-Ttbk1. A, B Volcano plot for the comparison between ASO-control and ASO-Ttbk1 treated group. The horizontal axis shows log2 (fold change) and the vertical axis means log10 (adjusted p-value). Cutoff values were set at ± 1.5 for FC and 0.05 for adj. p value. C Genes significantly altered by ASO-Ttbk1 treatment compared to ASO-control in the venn diagram. Cutoff values were set at ± 1.5 for FC and 0.05 for adj. p value. D List of 11 genes commonly and significantly altered by ASO-Ttbk1#1 or #2 treatment. The numbers represent the Log2 (Fold change). E Results of pathway enrichment analysis by Reactome for genes significantly altered by ASO-Ttbk1#1 treatment. F Top list of gene set enrichment analysis (GSEA) by ASO-Ttbk1#1 and #2 treatment. NES; Normalized enrichment Score. All Adj. p values were below 0.01. G Fold change in genes involved in antigen presentation by ASO-Ttbk1#1 and #2 treatment

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Acta Neuropathologica Communications

ISSN: 2051-5960

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