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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice

Fig. 3

Phosphorylated tau level in PS19 mice treated with ASO targeting Ttbk1. Protein expression levels determined by ELISA for p-tau for epitope pS396 (A, B), pT231 (C, D) and pT181 (E, F), and total tau in sarkosyl soluble (S2; A, C, E) and insoluble (P2; B, D, F) fractions isolated from the hippocampal brain tissue in PS19 mice after ASO treatment. * denotes < 0.05, ** < 0.01, *** < 0.00, **** < 0.0005 compared to ASO-control treated group as determined by one-way ANOVA and Dunnett’s multiple comparison (ASO-control n = 7; ASO-Ttbk1 #1 n = 6; ASO-Ttbk1 #2 n = 8 mice)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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