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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice

Fig. 1

Ttbk1 ASOs selectively suppress Ttbk1 expression in the temporal cortex of PS19. A The scheme of the experimental design for ASO-mouse Ttbk1 injection in PS19 mice. PS19 mice were injected with ASO-Ttbk1 #1 or #2, or ASO-control at 6 month of age. Mice are euthanized 8 weeks after the injection for qPCR, ELISA, and immunohistochemistry. B Body weight measurement at the end point. C, D qPCR analysis of mRNA level of temporal brain tissue for Ttbk1 (C) and Ttbk2 (D). Reduced mRNA level of Ttbk1 but not Ttbk2 was observed by ASO-Ttbk1 treatment. **** denotes < 0.0001 and *** denotes < 0.001 compared to ASO-control treated group as determined by one-way ANOVA and Dunnett’s multiple comparison (WT saline treated n = 6, ASO-control n = 7; ASO-Ttbk1 #1 n = 6; ASO-Ttbk1 #2 n = 8 mice)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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