Fig. 4

Collagen content and MRI fat degeneration. The graphs show the percentage of fibrosis in FSHD muscles without and with changes in fatty infiltration on T1w sequences in a 1-year MRI follow-up (no progression, n = 35; with progression, n = 10) and in b 2-year MRI follow-up (no progression, n = 21; with progression, n = 15). The graphs show the percentage of fibrosis in FSHD STIR− muscles without (n = 21), FSHD STIR+ muscles without (n = 14) and with (n = 10) changes in fatty infiltration on T1w sequences in c 1-year MRI follow-up and d 2-year MRI follow-up [FSHD STIR− muscles without (n = 18); FSHD STIR+ muscles without (n = 3); with (n = 15) progression]. The results are reported as mean ± SD. Comparison between two groups were done using Mann–Whitney test (^###p < 0.001, ^####p < 0.0001). Groups were compared using Kruskal–Wallis test (§§§p < 0.001) followed by Dunn’s test (*p < 0.05, ***p < 0.001)