Fig. 1
From: Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau
Tau filaments from the central nervous system of Tg2541 mice aged 4–25 weeks. a, Negative-stain electron microscopy images of filaments extracted from the brainstem of Tg2541 mice aged 4–24 weeks (w). Arrowheads in the first two panels point to short filaments. Scale bar, 200 nm. b, Immunogold negative-stain electron microscopy of Tau filaments extracted from the spinal cord of Tg2541 mice aged 5–25 weeks (w). Anti-tau antibody BR134 was used. Note the gold particles lining the filament surfaces. Scale bar, 100 nm