Fig. 7

Dally-like protein is a target of TDP-43^WT in MBNs where it mediates TDP-43 dependent working memory deficits. a Dlp antibody labelling in mushroom bodies shows age and TDP-43 dependent reduction. Genotypes (w¹¹¹⁸; YFP and w¹¹¹⁸; TDP-43^WT::YFP mCD8::RFP), stainings (Dlp, YFP, RFP) and ages (1 and ~ 50 days old), as indicated. b Quantification of age and TDP-43 dependent changes in Dlp signal intensity within MBLs. c Mean distance moved and d alternation per trial in males overexpressing Dlp (w¹¹¹⁸;; dlp OE), TDP-43^WT (w¹¹¹⁸; TDP-43^WT::YFP) or both (w¹¹¹⁸; TDP-43^WT::YFP; dlp OE) compared to w¹¹¹⁸ genetic background controls. Grey dotted line represents control group median. Scale bar = 50 mm. Data for TDP-43^G298S presented in Fig. 7-supplement 1. * = P < 0.05, ** = P < 0.01