Fig. 6
mRNAs enriched with TDP-43 in Drosophila models of proteinopathy in FTD and ALS. a Volcano plot displaying mRNAs enriched with TDP-43. Y-axis depicts Log2 Fold Change after subtraction of YFP control values (see Materials and Methods). A small number of targets showing greatest enrichment with high confidence are highlighted with blue circles (log2 Fold Change > 2 and P < 1 × 10–14). b Schematic showing subsets of neurons in fly models of FTD (MBs, above) and ALS (MNs, below), and Venn diagram depicting enriched mRNAs unique to MB and MN circuits, and overlapping between models. c Volcano plot displaying mRNAs enriched in TDP-43 complexes that are MB-specific (blue) or shared between MB and MN models (green); saturated green circles indicate shared targets that show log2 Fold Change > 3 and P < 1 × 10–14; blue circles indicate MB targets with log2 Fold Change > 2 and P < 1 × 10–14. Data for TDP-43G298S presented in Fig. 6-supplement 1