Fig. 3
Overexpression of TDP-43 in MBNs results in spatial working memory deficits. a Schematic of the spatial working memory assay showing the sequence of decisions made by a fly (black text) and those coded as alternations (blue text). Alternation scores were calculated as the number of alternations (Nalt) divided by alternation attempts (Amax). b Young (1–3 days old) flies with TDP-43WT YFP OE show significant increases in movement. c Despite moving more, these flies show reduced alternation percent when compared with controls. Grey dotted line = control group median. A% = alternation percent. * = P < 0.05; ** = P < 0.01; *** = P < 0.001