Fig. 1

Tau pathology across diseases. Tau pathology is found exclusively in neurons in AD and PART, which are mixed 3R/4R tauopathies. In 4R tauopathies, such as PSP, CBD, and GGT, tau pathology is seen in neurons, astrocytes, and oligodendrocytes. Both PiD, a 3R tauopathy, and AGD, a 4R tauopathy, show primarily neuronal pathology with rare astrocytic involvement. Although neuronal inclusions in CTE are composed of both 3R and 4R tau, the astrocytic pathology is predominantly 4R. Scale bar = 20 μm