Fig. 3

Impact of alpha-synuclein monomer on SAA kinetic features. A Alpha-synuclein (aSyn) monomer-dependent change of the second fastest Lag phase (TT2). B aSyn monomer-dependent change of average Lag phase (LAG). In A and B, each line represents one CSF-sample (13 in total) which was measured with both, the “slow-kinetic”- and “fast-kinetic”-aSyn monomer. Patients’ MoCA-scores are coded by color: MoCA ≥ 25, blue; MoCA 24–20, green; MoCA 19–15, orange; MoCA < 15, red. C SAA aggregation curves of one sample (MoCA ≥ 25) with 4 replicates, measured with “slow-kinetic”- (light blue) and “fast-kinetic”-aSyn monomer (dark blue). D SAA aggregation curves of one sample (MoCA 19–15) with 4 replicates, measured with “slow-kinetic”- (orange) and “fast-kinetic”-aSyn monomer (dark orange)