Fig. 2

Correlation of the second fastest lag phase with clinical features. A Correlation of the second fastest lag phase (TT2) with cognitive performance as quantified by the Montreal cognitive assessment (MoCA). B TT2 for patients with and without cognitive impairment, defined as MoCA < 24. Comparison by Mann–Whitney U test, r = 0.482, p < 0.001. The orange dashed line indicates the 27h threshold used for the calculation of sensitivity and specificity described in the text. C Correlation of TT2 with motor symptoms reflected by the Unified Parkinson’s disease rating scale part III (UPDRS-III). In A-C, each marker represents one patient sample. In A and C, nonlinear regression and 95% confidential interval are indicated by blue line and blue-grey area. In B, box indicates 25 and 75 percentiles, whiskers indicate the range, blue line indicates median