Fig. 7

Retarded growth of metastatic tumors in the brains of mice treated with MCC950. a Representative confocal micrographs (maximum intensity projections of z-stacks) showing 4T1-tdT tumors in mice treated with vehicle (DMSO in PBS) or 10 mg/kg MCC950 7 days after the injection of the tumor cells. b Quantitative analysis of tumor-covered pixels compared to all pixels. Graphs represent the average ± SEM (N = 3 independent experiments, n = 5 sections/animal, 16 ROIs/5 sections). *** P ≤ 0.001 (unpaired Student’s t test)