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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Inflammasome activation in peritumoral astrocytes is a key player in breast cancer brain metastasis development

Fig. 1

Expression of inflammasome components in peritumoral astrocytes in human TNBC brain metastases. a Representative immunofluorescence micrographs (maximum intensity projections of z-stacks) showing colocalization of NLRP3 and ASC with GFAP in advanced human TNBC brain metastases. A total of 95.3% of NLRP3-positive pixels and 98.8% of ASC-positive pixels colocalized with GFAP. b Representative immunofluorescence micrographs showing the colocalization of NLRP3 and IL-1β with GFAP in human TNBC brain metastases. Seventy-six percent of NLRP3-positive pixels and 74% of IL-1β-positive pixels colocalized with GFAP. Blue: nuclei (Hoechst 33342 staining) in all figures

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Acta Neuropathologica Communications

ISSN: 2051-5960

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