Table 2 Univariate and multivariate binomial logistic regression analyses of risk factors associated with LATE-NC, argyrophilic grains, and severe neuronal loss in the amygdala

LATE-NC

  Age at death

1.16 (1.05–1.27)

0.0029**

1.27 (1.03–1.56)

0.0264*

  Sex (female)

3.15 (0.80–12.43)

0.1013

Excluded

–

  Braak NFT stages IV

4.50 (1.04–19.51)

0.0445*

0.44 (0.05–3.90)

0.4616

  Presence of Aβ deposits

2.33 (0.55–9.86)

0.2492

Excluded

–

  Thal phases 3–4

1.34 (0.31–5.85)

0.6947

Excluded

–

  Amygdala GFA stage 4

21.78 (4.43–107.13)

 < 0.001**

40.7 (2.81–590.25)

0.0066**

  Presence of AGs

9.78 (1.89–50.59)

0.0066**

Excluded

–

  Saito AG stages II–III

13.74 (2.99–63.20)

 < 0.001**

2.02 (0.27–14.88)

0.4915

  Infarctions in the neocortex

0.58 (0.07–5.16)

0.6255

Excluded

-

  Infarctions in the subcortical nuclei

0.90 (0.21–3.91)

0.8934

Excluded

–

Argyrophilic grains

  Age at death

1.07 (1.02–1.13)

0.0058**

1.07 (1.00–1.14)

0.0428*

  Sex (female)

2.03 (0.64–6.44)

0.2283

Excluded

–

  Braak NFT stage IV

2.00 (0.57–7.00)

0.2780

0.39 (0.07–2.24)

0.2905

  Presence of Aβ deposits

0.84 (0.32–2.20)

0.7227

Excluded

–

  Thal phase 4

1.19 (0.18–7.65)

0.8513

Excluded

–

  Amygdala GFA stage 4

16.13 (3.20–81.25)

 < 0.001**

12.43 (1.97–78.37)

0.0073**

  Presence of LATE-NC

9.78 (1.89–50.59)

0.0066**

1.70 (0.22–13.26)

0.6111

  Infarctions in the neocortex

2.11 (0.54–8.23)

0.2817

Excluded

–

  Infarctions in the subcortical nuclei

0.91 (0.30–2.70)

0.8599

Excluded

–

Severe neuronal loss in the amygdala

  Age at death

1.05 (0.96–1.15)

0.2858

0.98 (0.88–1.10)

0.7429

  Sex (female)

0.42 (0.04–3.97)

0.4491

Excluded

–

  Braak NFT stage IV

1.27 (0.13–12.50)

0.8361

Excluded

–

  Presence of Aβ deposits

0.20 (0.02–1.91)

0.1632

Excluded

–

  Amygdala GFA stage 4

3.39 (0.51–22.75)

0.2080

0.73 (0.06–8.24)

0.7978

  Saito AG stage I

1.61 (0.16–16.09)

0.6846

Excluded

–

  Saito AG stages II–III

18.33 (1.88–178.98)

0.0123*

21.00 (1.34–328.20)

0.0300*

  Saito AG stage III

130.00 (9.62–1757.58)

 < 0.001**

Excluded

–

  Presence of LATE-NC

4.92 (0.71–34.06)

0.1068

1.67 (0.12–23.23)

0.7026

  Infarctions in the neocortex

1.96 (0.18–21.02)

0.5772

Excluded

–

  Infarctions in the subcortical nuclei

0.70 (0.07–7.16)

0.7637

Excluded

–