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Table 3 MVP densities: test for association with ordinal clinical, neuropathological and genetic (APOE) variables

From: A neuropathologic feature of brain aging: multi-lumen vascular profiles

 

MVP Density (#/µm)

Statistical significance

Demographics, median density (IQR)

  

  Sex

  

    Male

1.18 (1.34)

NS

    Female

1.38 (1.31)

 

Neuropathological variables

  

  Atherosclerosis

 

NS

    None

0.82 (0.42)

 

    Mild

1.63 (1.62)

 

    Moderate

1.39 (1.21)

 

    Severe

1.36 (1.29)

 

      Almost occluded

0.97 (0.85)

 

  B-ASC

 

NS

    None

0.92 (0.92)

 

    Mild

1.54 (1.17)

 

    Moderate

1.31 (1.60)

 

    Severe

0.80 (NA)

 

Genetic variables

  

  APOE genotype

 

NS

ℇ2/ℇ3

1.30 (1.73)

 

ℇ3/ℇ3

1.32 (1.01)

 

ℇ3/ℇ4

1.19 (1.62)

 
  1. *A Mann–Whitney U (Wilcoxon Rank Sum) test was applied. To correct for multiple comparisons, an adjusted significance level of 0.00002 (17 comparisons) was used to determine significance
  2. IQR interquartile range; NS not significant at P < 0.05; MVP multi-lumen vascular profiles; B-ASC brain arteriolosclerosis as defined previously [22, 23]