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Table 2 Prevalence ratios (PR) with 95% CI* between dichotomous clinical variables and lesion counts of frontal cortex MVPs, microinfarcts, and total brain infarcts

From: A neuropathologic feature of brain aging: multi-lumen vascular profiles

Clinical history (mostly by self-report)

MVPs in frontal cortex

Microinfarcts

Total brain infarcts

 

PR

95% CI

PR

95% CI

PR

95% CI

Myocardial infarction

1.58

(0.745, 3.33)

0.98

(0.48, 2.009)

1.34

(0.595, 3.038)

Chronic heart failure

0.89

(0.449, 1.765)

1.42

(0.705, 2.85)

0.98

(0.431, 2.237)

Hypertension

1.91

(0.908, 4.026)

0.67

(0.232, 1.937)

1.91

(0.673, 5.437)

Stroke

0.75

(0.355, 1.592)

3.88

(1.824, 8.249)

3.19

(1.607, 6.34)

Transient ischemic attack (TIA)

0.81

(0.304, 2.176)

1.16

(0.451, 3)

1.69

(0.706, 4.051)

Brain trauma

2.07

(1.094, 3.924)

1.22

(0.545, 2.725)

2.19

(0.938, 5.123)

Diabetes

1.25

(0.608, 2.582)

2.50

(1.272, 4.903)

2.87

(1.414, 5.812)

Angina pectoralis

1.04

(0.485, 2.249)

0.54

(0.184, 1.574)

1.03

(0.499, 2.107)

Peripheral vascular disease

1.66

(0.842, 3.271)

1.97

(0.888, 4.377)

1.55

(0.622, 3.859)

Coronary artery bypass graft

2.48

(0.802, 7.687)

1.41

(0.476, 4.173)

1.06

(0.337, 3.332)

Smoking

1.52

(0.747, 3.093)

1.03

(0.353, 2.987)

0.62

(0.276, 1.401)

  1. *Zero-inflated negative binomial regression was performed including age at death and sex in the model. Nominal confidence intervals (95% CI) are shown, which are unadjusted for multiple comparisons. Bold: nominally statistically significant at p < 0.05