Fig. 3

Relationship between age at death and MVP density (counts per 10⁷ microns²). Cases from the UKPD and the UK-ADRC cohort (blue dots) were combined in order to determine the association between age at death and MVP density. A scatter plot was used to show each case’s MVP density with corresponding age at death. Using a Spearman’s rho test, the correlation between age at death and MVP density was 0.60 with a p-value of < 0.0001. Cases with severe CAA (red dots) from the UK-ADRC and 2 with CTE (purple dots) and aged-matched controls (yellow dots) were also included. Comb. combined, U. university, CAA cerebral amyloid angiopathy, CTE chronic traumatic encephalopathy, MVP multi-lumen vascular profiles